CNS Vital Signs (CNSVS) Computerized Neurocognitive Testing
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The CNS Vital Signs computerized neuropsychological test platform is used to measure brain function or cognitive function while examining testing effort (symptom validity) for both children and adults (ages 8 – 90 years). The test is used to rapidly evaluate and to subsequently track and manage neuropsychiatric symptoms, behaviors, and comorbidities. Results of testing are provided immediately after a test is completed and typically taken in context with other relevant clinical information such as history, physical examination, other psychological or neuropsychological tests, lab results, imaging studies, etc., in accordance with good clinical practice standards. Clinicians and researchers may choose an appropriate test set from ten normed neuropsychological tests along with an additional sixteen research subtests as well as over 50 (PRO) patient reported outcome questionnaires or instruments.
Technically, the platform runs on Windows, IOS and web environments. Response times are measured with millisecond precision. Symptom validity or invalid responses are measured as embedded indicators within the neurocognitive tests. There are an infinite number of test forms. The majority of subtests are based off of conventional “pen and paper” neuropsychological tests (e.g., the Rey Memory Test, Stroop).
- The Verbal Memory Test measuring learning and recognition memory for words; immediate and delayed recall
- The Visual Memory Test measuring learning and recognition memory for geometric shapes; immediate and delayed recall
- The Finger Tapping Test measuring ability to perform hand motor movements to produce and satisfy an intention towards a manual action and goal
- The Symbol Digit Coding Test measures ability to recognizes and processes information i.e., perceiving, attending/responding to incoming information, motor speed, fine motor coordination, and visual-perceptual ability
- The Stroop Test measures how quickly a subject can react, in milliseconds, to a simple and increasingly complex direction set and inhibition / disinhibition of frontal or executive tasks
- The Shifting Attention Test measures the ability to recognize and respond to rules, categories, and manages or navigates rapid decision making.
- The CPT or Continuous Performance Test measures ability to track and respond to a single defined stimulus over lengthy periods of time while performing vigilance and response inhibition quickly and accurately.
- The Perception of Emotions Test measures how well a subject can perceive, identify, and react to specific emotions.
- The Non‐Verbal Reasoning Test measures how well a subject can perceive and understand the meaning of visual or abstract information and recognizing relationships between visual‐abstract concepts.
- The Four Part CPT Test (N-Back) measures a subject's working memory or how well a subject can perceive and attend to symbols using short-term memory processes and sustained attention or how well a subject can direct and focus cognitive activity on specific stimuli.
- Complex Memory
- Verbal Memory
- Visual Memory
- Psychomotor Speed
- Reaction time
- Complex Attention
- Cognitive Flexibility
- Processing speed
- Executive function
- Social Acuity
- Working Memory
- Sustained Attention
- Visual or Simple Attention
- Motor Speed
Patient Reported Symptoms and Outcomes Scales
Most of the 50+ (PRO) Patient Reported Outcome questionnaires or instruments made available in the in the CNS Vital Signs assessment platform are well known and were commonly used by healthcare providers as paper questionnaires. Patients self-report and rate the severity of their illness or impairment. Historically, the use of such rating scales has contributed to the assessment by ensuring thoroughness by including a patient’s subjective input of their condition, helping to facilitate the determination of response to treatment and disease course over time.
|Patient Reported Outcome Questionnaires and Instruments||Number of Questions|
|Medical Outcomes Survey (MOS) SF-36||36|
|NeuroPsych Questionnaire Brief e.g. follow-up||45|
|Zung Self-Rating Depression Scale||20|
|Zung Self-Rating Anxiety Scale||20|
|Stanford Geriatric Depression Scale||30|
|Stanford Geriatric Depression Scale||15|
|Epworth Sleepiness Scale||8|
|Pittsburgh Sleep Quality Index||10|
|Alertness Rating Scale||1|
|Alcohol Use Disorders Identification Test (AUDIT) e.g., SBIRT Screens||10|
|Drug Use Questionnaire (DAST) e.g., SBIRT Screens||20|
|Pain Catastrophizing Scale (PCS)||13|
|Adult ADHD Self-Report Scale (ASRS-v1.1) Symptom Checklist||18|
|Vanderbilt ADHD Diagnostic Parent Rating Scale||53|
|Vanderbilt ADHD Diagnostic Teacher Rating Scale||43|
|Vanderbilt Assessment Follow-up Parent Rating Scale||38|
|Vanderbilt Assessment Follow-up Teacher Rating Scale||38|
|Pediatric Symptom Checklist (PSC)||35|
|Pediatric Symptom Checklist-Youth Report (Y-PSC)||35|
|Pediatric Symptom Checklist (PSC-17)||17|
|Screen for Child Anxiety Related Disorders (SCARED) Child Version||41|
|Screen for Child Anxiety Related Disorders (SCARED) Parent Version||41|
|Child Obsessive-Compulsive Disorder Inventory (OCD-C)||20|
|Social Anxiety Scale for Children and Adolescents (SASCA)||20|
|Childhood Cancer Survivor Study Neurocognitive Questionnaire (CCSS)||25|
|Neurobehavioral Symptom Inventory (NSI)||22|
|PTSD Checklist (PCL-5)||20|
|PTSD Checklist - Civilian Version (PCL-C)||17|
|PTSD Checklist - Military Version (PCL-M)||17|
|PTSD Checklist - Stressor Specific Version (PCL-S)||17|
|Combat Exposure Scale (CES)||7|
|Life Events Checklist (LEC)||25|
|Dizziness Handicap Inventory (DHI)||20|
|Adult Obsessive-Compulsive Disorder Inventory (OCD-A)||20|
|Head Injury Questionnaire (HIQ)||90|
|Memory Questionnaire (MEMQ)||27|
|Deployment Risk and Resiliency Inventory (DRRI)|
|DRRI Section A: Pre-Deployment Life Events||15|
|DRRI Section B: Childhood Experiences||15|
|DRRI Section C: Training and Deployment Preparation||14|
|DRRI Section D: Deployment Environment||20|
|DRRI Section E: Life and Family Concerns||14|
|DRRI Section F: Unit Support||12|
|DRRI Section G: Relationship Within Unit||14|
|DRRI Section H: Deployment Concerns||15|
|DRRI Section I: Combat Experiences||15|
|DRRI Section J: Post-Battle Experiences||20|
|DRRI Section K: Exposure to Nuclear, Biological, Chemical Agents||15|
|DRRI Section L: Post-Deployment Support||20|
|DRRI Section M: Post-Deployment Life Events||17|
Uses for CNS Vital Signs
CNS Vital Signs is utilized by medical providers and researchers to evaluate and manage patients presenting with a psychological or neurological complaints as well as to test drug effect. CNS Vital Signs was designed to be used in busy clinical and research settings for a variety of populations such as:
Neurodevelopmental Conditions (e.g., AD/HD, Asperger's, etc.)
Neuropsychiatric (e.g., Pain, Depression/Anxiety, Substance Abuse,PTSD, Eating Disorders etc.)
Neurotrauma (e.g., TBI, Brain Injury Rehabilitation Neurocognitive manifestations in conditions such as Cancer, Obesity, Post-surgery, Mild Hepatic Encephalopathy, Metabolic / Diabetes, Cardiovascular, Prion or Lyme Disease, Exercise / Human Performance, Neurotoxicity, Genetic Phenotype, Medication Effects, HIV - HAND, etc. as well as aid in the monitoring of their progression (e.g. rehabilitation), and measuring the response of the disorder to treatment.
- Clinical Psychology and Neuropsychology
- Neuropsychological test
- Cognitive neuropsychology
- Cognitive test
- Computer-based assessment
- Developmental-Behavioral Screening and Surveillance
- Psychological Testing
- Attention Deficit Hyperactivity Disorder
- MCI - Mild Cognitive Impairment Disorder
- Behavioral Neurology and Neuropsychiatry
- Child and Adolescent Psychiatry and Behavioral and Developmental Pediatrics
- Krishna R, Grinn M, Giordano N, Thirunavukkarasu M, Tadi P, Das S. Diagnostic confirmation of mild traumatic brain injury by diffusion tensor imaging: a case report. J Med Case Rep. 2012 Feb 16;6(1):66. doi: 10.1186/1752-1947-6-66. PubMed PMID: 22339800; PubMed Central PMCID: PMC3299601.
- Bojar I, Wojcik-Fatla A, Owoc A, Lewinski A. Polymorphisms of apolipoprotein E gene and cognitive functions of postmenopausal women, measured by battery of computer tests - Central Nervous System Vital Signs. Neuro Endocrinol Lett. 2012;33(4):385-92. PubMed PMID: 22936261.
- Iverson GL, Brooks BL, Langenecker SA, Young AH. Identifying a cognitive impairment subgroup in adults with mood disorders. J Affect Disord. 2011 Aug;132(3):360-7. doi: 10.1016/j.jad.2011.03.001. Epub 2011 Mar 25. PubMed PMID: 21439647.
- Brooks BL, Barlow KM. A methodology for assessing treatment response in Hashimoto's encephalopathy: a case study demonstrating repeated computerized neuropsychological testing. J Child Neurol. 2011 Jun;26(6):786-91. doi: 10.1177/0883073810391532. Epub 2011 Feb 10. PubMed PMID: 21311082.
- King AL, Valença AM, E Silva AC, Cerqueira AC, Ferraz LM, Nardi AE. Huntington's Disease: Two-Year Observational Follow-Up of Executive Function Evaluation with CNS Vital Signs Test in an Adult Patient. Case Rep Med. 2011;2011:385894. doi: 10.1155/2011/385894. Epub 2011 Dec 4. PubMed PMID: 22203851; PubMed Central PMCID: PMC3235665.
- Iverson GL, Brooks BL, Young AH. Rapid computerized assessment of neurocognitive deficits in bipolar disorder. Appl Neuropsychol. 2009 Jul;16(3):207-13. doi: 10.1080/09084280903098778. PubMed PMID: 20183173.
- Gualtieri CT, Johnson LG. A computerized test battery sensitive to mild and severe brain injury. Medscape J Med. 2008 Apr 15;10(4):90. PubMed PMID: 18504479; PubMed Central PMCID: PMC2390690.
- Gualtieri CT, Johnson LG. Reliability and validity of a computerized neurocognitive test battery, CNS Vital Signs. Arch Clin Neuropsychol. 2006 Oct;21(7):623-43. Epub 2006 Oct 2. PubMed PMID: 17014981.
- Gualtieri CT, Johnson LG. Comparative neurocognitive effects of 5 psychotropic anticonvulsants and lithium. MedGenMed. 2006 Aug 23;8(3):46. PubMed PMID: 17406176; PubMed Central PMCID: PMC1781293.
- Gualtieri CT, Johnson LG. Neurocognitive testing supports a broader concept of mild cognitive impairment. Am J Alzheimers Dis Other Demen. 2005 Nov-Dec;20(6):359-66. Erratum in: Am J Alzheimers Dis Other Demen. 2006 Mar-Apr;21(2):3 p preceding 73. PubMed PMID: 16396441. Dementia 5 (5): 266–81. PMID 7951684.