Neuronal Migration
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Work in progress, expect frequent changes. Help and feedback is welcome. See discussion page. |
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Contents
- 1 Preknowledge, Objectives and Competencies
- 2 Preknowledge
- 3 Competencies
- 4 Activities and Reading Material
- 5 Reading
- 6 Assignments
- 7 Assignment
- 8 Question
- 9 Question
- 10 Question
- 11 Question
- 12 Question
- 13 Question
- 14 Question
- 15 Additional study material
- 16 Media
- 17 Web Resources
- 18 Related Content
Preknowledge, Objectives and Competencies
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In this unit we will concentrate on the different way in which neuroblasts migrate to find their final position in the brain. We will examine the radial migration of neurons in the telencephalon, and how the different layers in cortex are formed by neurons with a different date of birth. We will also examine the derivatives of the rhombic lip and discuss how the tangential migration of neurons that it gives rise to translates to the adult organization of the hindbrain. |
At the end of this unit you should be able to:
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Activities and Reading Material
| During class, we will look at the process by which neuroblasts migrate from the neuroepithelium to their final position in the central nervous system. Using the diagrams provided we will examine the migration paths of the different populations of neuroblasts and how they relate to their final fate. We will identify the signalling mechanisms that guide and determine the final differentiation of neurons.
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- Purves et al. Chapter 22 (pp. 568-574)
- Jacobsen Chapter 8
Assignments
| After class, you are expected to review your notes and use the assigned reading material to contribute to the questions and definitions sections below. Please use the discussion page if you want to discuss any particular topic on the material. You are also welcome to add links to videos or audio files in the Media box or links to online resources in the Web Resources box below. |
Questions
| How are the neural crest cells specified? |
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| How does radial migration preserve the positional information present in the neural plate? |
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| What are the differences between the rostral and caudal rhombic lip? What is the relationship of each with the hindbrain rhombomeres? |
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| If you were to label a small number of neuronal progenitors in the neural ectoderm, what yould you expect the distribution of neurons in the brain to be like depending on whether the cells underwent radial or tangential migration? |
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Definitions
You should be able to provide a comprehensive functional and structural definition for the terms associated with this topic:
(Radial glia, cell adhesion molecules, tangential migration, radial migration, rhombic lip, neuroectoderm).
| Radial Glia: |
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| Cell Adhesion Molecules: |
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| Tangential Migration: |
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| Radial Migration: |
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| Rhombic Lip: |
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| Neuroectoderm: |
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Additional study material
Add Links to media resources here
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Related Content
Go back to the introductory page, return to Unit 7: Specification and Differentiation of Neural Elements, or continue with Unit 9: Axonal Pathfinding and the Formation and Organization of Cranial and Spinal Nerves.
