File:Simulated Connectivity Damage of Phineas Gage.png

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Modeling the path of the tamping iron through the Gage skull and its effects on white matter structure.

(a) The skull of Phineas Gage on display at the Warren Anatomical Museum at Harvard Medical School.

(b) ... This figure shows the set of possible rod trajectory centroids which satisfied each of the anatomical constraints. ...

(c) A rendering of the Gage skull with the best fit rod trajectory and example fiber pathways in the left hemisphere intersected by the rod. Graph theoretical metrics for assessing brain global network integration, segregation, and efficiency [92] were computed across each subject and averaged to measure the changes to topological, geometrical, and wiring cost properties.

(d) A view of the interior of the Gage skull showing the extent of fiber pathways intersected by the tamping iron in a sample subject (i.e. one having minimal spatial deformation to the Gage skull). The intersection and density of WM fibers between all possible pairs of GM parcellations was recorded, as was average fiber length and average fractional anisotropy (FA) integrated over each fiber.
Date Published: May 16, 2012. Uploaded to Wikimedia Commons: 2012-08-24
Source Van Horn JD, Irimia A, Torgerson CM, Chambers MC, Kikinis R, et al. (2012) Mapping Connectivity Damage in the Case of Phineas Gage. PLoS ONE 7(5): e37454. doi:10.1371/journal.pone.0037454
Author Van Horn JD, Irimia A, Torgerson CM, Chambers MC, Kikinis R, et al.
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current16:12, 24 August 2012Thumbnail for version as of 16:12, 24 August 20121,302 × 1,817 (3.54 MB)Was a bee{{Information |Description=Modeling the path of the tamping iron through the Gage skull and its effects on white matter structure. '''(a)''' The skull of Phineas Gage on display at the Warren Anatomical Museum at Harvard Medical School. '''(b)''' CT...
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