Specification and Differentiation of Tissues
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Work in progress, expect frequent changes. Help and feedback is welcome. See discussion page. |
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Contents
Preknowledge, Objectives and Competencies
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In this unit we will be introduced to some terms that are commonly used in developmental biology do describe the different events that lead to the acquisition of the cell's final fate. We will also explore some of the mechanisms that govern the process of morphogenesis, pattern formation and differentiation using the amphibian embryo as an example. |
At the end of this unit you should be able to:
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Activities and Reading Material
| During class, we will examine the different definitions and try to identify how the different processes may be identified experimentally. We will use the diagrams provided in the lecture notes to identify and label the different structures and use those as a platform to discuss some of the early processes of development
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S Gilbert Developmental Biology. Please note that the content of this text can only be navigated through search terms
Assignments
| After class, you are expected to review your notes and use the assigned reading material to find examples for each of the defined terms. You are expected to contribute to the questions and definitions sections below. Please use the discussion page if you want to discuss any particular topic on the material. You are also welcome to add links to videos or audio files in the Media box or links to online resources in the Web Resources box below. |
Questions
| What experiment would you perform to determine whether a given molecule plays a permissive or instructive role? How would you differentiate that on the basis of your results? |
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| What would you consider would be the advantages and disadvantages of depending on contact signals vs. morphogens for signalling during development? |
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| What factors do you think would influence the way in which morphogens are able to diffuse in the embryo? |
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Definitions
You should be able to provide a comprehensive definition, and examples for the terms associated with this topic:
(Competence, Commitment, Differentiation, Repression, Induction, Reciprocal Induction, Instructive signals, Permissive signals, Conditional Development, Autonomous Development, Planar Signals, Vertical Signals, Morphogens, Organizing Centres).
| Competence: |
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| Commitment: |
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| Differentiation: |
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| Repression: |
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| Induction: |
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| Reciprocal Induction: |
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| Instructive Signals: |
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| Permissive Signals: |
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| Conditional Development: |
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| Autonomous Development: |
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| Planar Signals: |
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| Vertical Signals: |
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| Morphogens: |
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| Organizing Centres: |
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Additional study material
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Related Content
Go back to the introductory page, return to Unit 1: From Fertilisation to Gastrulation or continue with Unit 3: Formation, Organization and Morphogenesis of the Neural Plate.
