Formation Organization and Morphogenesis of the Neural Plate
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Work in progress, expect frequent changes. Help and feedback is welcome. See discussion page. |
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Contents
- 1 Preknowledge, Objectives and Competencies
- 2 Preknowledge
- 3 Competencies
- 4 Activities and Reading Material
- 5 Reading
- 6 Assignments
- 7 Assignment
- 8 Question
- 9 Question
- 10 Question
- 11 Question
- 12 Question
- 13 Question
- 14 Question
- 15 Additional study material
- 16 Media
- 17 Web Resources
- 18 Related Content
Preknowledge, Objectives and Competencies
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In this unit we will build on prior knowledge to construct a more detailed view of the development of the neural tube. We will look at the different regions that can be identified in the neural plate, and how each of these relates to the adult morphology of the brain and spinal cord. We will look at the differences and implications of primary and secondary neurulation. We will look at some of the genes and molecules that contribute to these processes. We will also examine how these processes differ in the spinal cord and hindbrain. |
At the end of this unit you should be able to:
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Activities and Reading Material
| During class, we will look at the process by which the dorsal ectoderm differentiates into the neural plate. We will examine the early development of the neural tube. We will also examine the role that different genes and molecules play in each of these processes. Emphasis will be placed on how the early structures relate to the adult structures of the Central Nervous System. We will use the diagrams provided in the lecture notes to identify and label the different structures and use those as a platform to discuss some of the early processes of development. We will use the tables provided in the lecture notes to summarise the origin and roles of different genes and molecules during the processes examined in lecture.
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- Purves et al Chapter 22 (pp 547-562)
- Jacobsen Chapter 1 (Sections on neural induction and neurulation)
Assignments
| After class, you are expected to review your notes and use the assigned reading material to complete a descriptive table of the different genes and molecules involved in the early differentiation of the neural plate and neural tube. You are expected to contribute to the questions and definitions sections below. Please use the discussion page if you want to discuss any particular topic on the material. You are also welcome to add links to videos or audio files in the Media box or links to online resources in the Web Resources box below. |
Questions
| What are the differences in the mechanisms that determine the specification of the dorsal ectoderm in amphibians and chickens? |
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| What are the different extents of primary and secondary neurulation in fishes, birds and mammals?? |
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| Which mechanisms learned in Unit 2 could potentially be involved in the morphogenesis of the primary vesicles? |
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| What congenital conditions are associated with the processes described in this Unit? What is their incidence? Are there any preventive measures that can be taken to avoid them? |
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Definitions
You should be able to provide structural and functional definitions for the structures associated with this topic:
(Notochord, Neural Plate, Neural Folds, Neural Groove, Neural Crest, Floor Plate, Basal Plate, Alar Plate, Roof Plate, Ectodermal Placodes, Primary Neurulation, Secondary Neurulation, Pontine Flexure, Cephalic Flexure, Telencephalic Vesicle, Mesencephalic Vesicle, Rhombencephalic Vesicle).
| Notochord: |
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| Neural Plate: |
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| Neural Folds: |
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| Neural Groove: |
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| Neural Crest: |
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| Floor Plate: |
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| Basal Plate: |
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| Alar Plate: |
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| Roof Plate: |
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| Ectodermal Placodes: |
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| Primary Neurulation: |
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| Secondary Neurulation: |
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| Pontine Flexure: |
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| Cephalic Flexure: |
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| Cervical Flexure: |
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| Telencephalic Vesicle: |
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| Mesencephalic Vesicle: |
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| Thombencephalic Vesicle: |
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| Genes and molecules: Fill in the table |
| Molecule/Gene | Produced by/in | Acts on | Effect |
|---|---|---|---|
| Noggin | |||
| Chordin | |||
| Follistatin | |||
| BMPs | |||
| FGF | |||
| Cerebrus |
Additional study material
Add Links to media resources here
Add Links to Web Resources here
Related Content
Go back to the introductory page, return to Unit 2: Specification and Differentiation of Tissues or continue with Unit 4: Pattern Formation, Antero-Posterior (AP) and Dorso-Ventral (DV) Axes Formation.
